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a Regional Adult Cystic Fibrosis Unit, The
Cardiothoracic Centre, b Department of Medical Microbiology, c Royal Liverpool
University Hospitals, Liverpool L14 3PE, UK
Correspondence to: Dr M J Walshaw.
Received 8 September 1997; Returned to authors 9 January 1998; Revised version received 3 February 1998; Accepted for publication 13 February 1998
Whilst patient to patient spread of the respiratory pathogen
Burkholderia cepacia is well recognised between patients
with cystic fibrosis, prompting a strict segregation policy, cross colonisation between cystic fibrosis patients already infected with
B cepacia has not been described and surveys show a very low incidence of patients with more than one strain. Five adult cystic
fibrosis patients with B cepacia are presented who became cross colonised with a second B cepacia (UK epidemic)
strain, four of whom then died, three from the cepacia syndrome. These cases show that, amongst segregated patients, cross colonisation with
different B cepacia strains is possible, and even in these patients the acquisition of the UK epidemic strain may have a fatal
outcome. In future it may be necessary to segregate cystic fibrosis
patients colonised with the UK epidemic strain from all other patients
with cystic fibrosis.
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