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Thorax 1998;53:809-811 ( September )

Case report

Serum KL-6 level as a monitoring marker in a patient with pulmonary alveolar proteinosis Masamitsu Nakajima,a Toshiaki Manabe,b Yoshihito Niki,a Toshiharu Matsushimaa

a Division of Respiratory Diseases, Department of Internal Medicine, b Department of Pathology, c Kawasaki Medical School, 577 Matsushima, Kurashiki 701-0192, Japan

Correspondence to: Dr M Nakajima.

Received 13 August 1996; Returned to authors 2 April 1997; Revised version received 7 May 1997; Accepted for publication 30 May 1997

A raised serum level of KL-6 is known to exist in active pulmonary fibrosis and KL-6 may be produced and secreted by type II pneumocytes. A case is described of pulmonary alveolar proteinosis with high serum KL-6 levels. The serum KL-6 level decreased after whole lung washing and correlated with symptoms, opacities on the chest radiograph, and arterial blood gas measurements. The serum KL-6 level may represent a useful marker for pulmonary alveolar proteinosis.

Keywords: KL-6; pulmonary alveolar proteinosis; tumour marker

© 1998 by Thorax


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