| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
|
|
|
|
|||||||||||||
|
|
|||||||||||||||
a Institute for
Medical Technology Assessment, Erasmus University Rotterdam, 3000 DR
Rotterdam, The Netherlands, b Atrium Hospital, Heerlen, The Netherlands
Correspondence to: Dr M Rutten-van Mölken.
Received 15 February 1999; Returned to authors 11 May 1999; Revised version received 30 June 1999; Accepted for publication 12 July 1999
BACKGROUND
The Chronic
Respiratory Questionnaire (CRQ) and the St George's Respiratory
Questionnaire (SGRQ) are the two most widely used quality of life
questionnaires in chronic obstructive pulmonary disease (COPD). A study
was undertaken to compare directly the self-administered version of the
CRQ and the SGRQ with respect to feasibility, internal consistency,
validity, and sensitivity to changes resulting from bronchodilator therapy.
METHODSOne hundred
and forty four patients with moderate or severe COPD were randomly
assigned to receive three months of treatment with either salmeterol,
salmeterol + ipratropium bromide, or placebo. Quality of life was
measured at baseline and after 12 weeks of treatment.
RESULTSThe
proportions of missing values per patient were low for both
questionnaires (0.54% for the CRQ and 2% for the SGRQ). The internal
consistency was good for both questionnaires (Cronbach's 
coefficients 
0.84 for the CRQ and 0.76 for the SGRQ). Factor analysis confirmed the original domain structure of the CRQ but not of
the SGRQ. Correlations with forced expiratory volume in one second
(FEV1) % predicted and peak expiratory flow rate (PEFR) were low for both questionnaires but better for the SGRQ than for the
CRQ. The ability to discriminate between subjects with different levels
of FEV1 was somewhat better for the SGRQ. The correlations
with symptom scores were comparable for both questionnaires. Cross
sectionally, the scores of the two questionnaires were moderately to
highly correlated (coefficients ranged from 0.35 to 0.72). Longitudinally, these correlations were lower (coefficients ranged from
0.17 to 0.54) but were still significant. The CRQ total and emotions
score and the SGRQ symptoms score were the most responsive to change.
The SGRQ symptoms domain was the only domain where the improvement in
patients receiving combination treatment crossed the threshold for
clinical relevance.
CONCLUSIONSSince this
analysis of reliability, validity, and responsiveness to change did not
clearly favour one instrument above the other, the choice between the
CRQ and the SGRQ can be based on other considerations such as the
required sample size or the availability of reference values.
This article has been cited by other articles:
|
|
 |
|
  G. J. Rodrigo, L. J. Nannini, and R. Rodriguez-Roisin Safety of Long-Acting {beta}-Agonists in Stable COPD: A Systematic Review Chest, May 1, 2008; 133(5): 1079 - 1087. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Harnisch, S. Brosch, M. Schmidt, and R. Hagen Breathing and Voice Quality After Surgical Treatment for Bilateral Vocal Cord Paralysis Arch Otolaryngol Head Neck Surg, March 1, 2008; 134(3): 278 - 284. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Cazzola, W. MacNee, F. J. Martinez, K. F. Rabe, L. G. Franciosi, P. J. Barnes, V. Brusasco, P. S. Burge, P. M. A. Calverley, B. R. Celli, et al. Outcomes for COPD pharmacological trials: from lung function to biomarkers Eur. Respir. J., February 1, 2008; 31(2): 416 - 469. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. E. O'Donnell Impacting patient-centred outcomes in COPD: breathlessness and exercise tolerance Eur. Respir. Rev., December 1, 2006; 15(99): 37 - 41. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Decramer Tiotropium as essential maintenance therapy in COPD Eur. Respir. Rev., December 1, 2006; 15(99): 51 - 57. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Esteban, J.M. Quintana, M. Aburto, J. Moraza, and A. Capelastegui A simple score for assessing stable chronic obstructive pulmonary disease QJM, November 1, 2006; 99(11): 751 - 759. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Tonnesen, K. Mikkelsen, and L. Bremann Nurse-Conducted Smoking Cessation in Patients With COPD Using Nicotine Sublingual Tablets and Behavioral Support. Chest, August 1, 2006; 130(2): 334 - 342. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Berry, N. E. Adair, and W. J. Rejeski Use of Peak Oxygen Consumption in Predicting Physical Function and Quality of Life in COPD Patients Chest, June 1, 2006; 129(6): 1516 - 1522. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V Brusasco, R Hodder, M Miravitlles, L Korducki, L Towse, and S Kesten Health outcomes following treatment for six months with once daily tiotropium compared with twice daily salmeterol in patients with COPD Thorax, January 1, 2006; 58(5): 399 - 404. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Martinez-Garcia, M. Perpina-Tordera, P. Roman-Sanchez, and J. J. Soler-Cataluna Quality-of-Life Determinants in Patients With Clinically Stable Bronchiectasis Chest, August 1, 2005; 128(2): 739 - 745. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Decramer, R Gosselink, M Rutten-Van Molken, J Buffels, O Van Schayck, P-A Gevenois, R Pellegrino, E Derom, and W De Backer Assessment of progression of COPD: report of a workshop held in Leuven, 11-12 March 2004 Thorax, April 1, 2005; 60(4): 335 - 342. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B J Smith, S L Appleton, A J Veale, H J McElroy, D Veljkovic, and L Saccoia Eformoterol n-of-1 trials in chronic obstructive pulmonary disease poorly reversible to salbutamol Chronic Respiratory Disease, April 1, 2004; 1(2): 63 - 69. [Abstract] [PDF]
|
|
|
|
|
|
D. P. Tashkin and C. B. Cooper The Role of Long-Acting Bronchodilators in the Management of Stable COPD Chest, January 1, 2004; 125(1): 249 - 259. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. J. Schunemann, G. H. Guyatt, L. Griffith, D. Stubbing, and R. Goldstein A Randomized Controlled Trial To Evaluate the Effect of Informing Patients About Their Pretreatment Responses to Two Respiratory Questionnaires Chest, November 1, 2002; 122(5): 1701 - 1708. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Hermiz, E. Comino, G. Marks, K. Daffurn, S. Wilson, and M. Harris Randomised controlled trial of home based care of patients with chronic obstructive pulmonary disease BMJ, October 26, 2002; 325(7370): 938 - 938. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. F. Donohue, J. A. van Noord, E. D. Bateman, S. J. Langley, A. Lee, T. J. Witek Jr, S. Kesten, and L. Towse A 6-Month, Placebo-Controlled Study Comparing Lung Function and Health Status Changes in COPD Patients Treated With Tiotropium or Salmeterol* Chest, July 1, 2002; 122(1): 47 - 55. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. F. Heijdra, V. M. Pinto-Plata, L. A. Kenney, J. Rassulo, and B. R. Celli Cough and Phlegm Are Important Predictors of Health Status in Smokers Without COPD* Chest, May 1, 2002; 121(5): 1427 - 1433. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Vincken, J.A. van Noord, A.P.M. Greefhorst, Th.A. Bantje, S. Kesten, L. Korducki, and P.J.G. Cornelissen Improved health outcomes in patients with COPD during 1 yr's treatment with tiotropium Eur. Respir. J., February 1, 2002; 19(2): 209 - 216. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P W Jones Health status measurement in chronic obstructive pulmonary disease Thorax, November 1, 2001; 56(11): 880 - 887. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
