| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
|
|
|
|
|||||||||||||
|
|
|||||||||||||||
Aintree Chest
Centre, University Hospital Aintree, University Department of Medicine,
Liverpool and Department of Biological Sciences, Salford University, UK
Correspondence to: Professor P M A Calverley, University Clinical Departments, University Hospital Aintree, Longmoor Lane, Liverpool L9 7AL, UK email: pmacal{at}liverpool.ac.uk
Received 30 April 1999; Returned to authors 9 July 1999; Revised version received 19 April 2000; Accepted for publication 19 April 2000
BACKGROUND
Chronic
cough is associated with an increased sensitivity to inhaled capsaicin
in a number of conditions but there are no data for patients with more
severe asthma or chronic obstructive pulmonary disease (COPD).
Moreover, the relationships between the capsaicin response (expressed
as the concentration of capsaicin provoking five coughs, C5),
self-reported cough, and routine medication is not known.
METHODSThe cough
response to capsaicin in 53 subjects with asthma, 56 subjects with
COPD, and 96 healthy individuals was recorded and compared with a
number of subjective measures of self-reported cough, measures of
airway obstruction, and prescribed medication. In asthmatic subjects
the relationships between the cough response to capsaicin and mean
daily peak flow variability and non-specific bronchial
hyperresponsiveness to histamine were also examined.
RESULTSSubjects with
asthma (median C5 = 62 mM) and COPD (median C5 = 31 mM) were
similarly sensitive to capsaicin and both were more reactive than
normal subjects (median C5 >500 mM). Capsaicin sensitivity was
related to symptomatic cough as measured by the diary card score in
both asthma and COPD (r = -0.38 and
r = -0.44, respectively), but only in
asthma and not COPD when measured using a visual analogue score
(r = -0.32 and r = -0.05, respectively). Capsaicin sensitivity was independent of the
degree of airway obstruction and in asthmatics was not related to PEF
variability or PC20 for histamine. The response to
capsaicin was not related to treatment with inhaled corticosteroids but
was increased in those using anticholinergic agents in both conditions.
CONCLUSIONSThese data
suggest that an increased cough reflex, as measured by capsaicin
responsiveness, is an important contributor to the presence of cough in
asthma and COPD, rather than cough being simply secondary to excessive
airway secretions. The lack of any relationship between capsaicin
responsiveness and airflow limitation as measured by the
FEV1 suggests that the mechanisms producing cough are
likely to be different from those causing airways obstruction, at least
in patients with COPD.
This article has been cited by other articles:
|
|
 |
|
  G. Zhang, R.-L. Lin, M. E. Wiggers, and L.-Y. Lee Sensitizing effects of chronic exposure and acute inhalation of ovalbumin aerosol on pulmonary C fibers in rats J Appl Physiol, July 1, 2008; 105(1): 128 - 138. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Ni and L.-Y. Lee Effect of increasing temperature on TRPV1-mediated responses in isolated rat pulmonary sensory neurons Am J Physiol Lung Cell Mol Physiol, March 1, 2008; 294(3): L563 - L571. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L.P.A. McGarvey, L. Polley, and J. MacMahon Review Series: Chronic cough: Common causes and current guidelines Chronic Respiratory Disease, November 1, 2007; 4(4): 215 - 223. [Abstract] [PDF]
|
|
|
|
 |
|
 A. H. Morice, M. S. Menon, S. A. Mulrennan, C. F. Everett, C. Wright, J. Jackson, and R. Thompson Opiate Therapy in Chronic Cough Am. J. Respir. Crit. Care Med., February 15, 2007; 175(4): 312 - 315. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H-K Park, S-Y Oh, T-B Kim, J-W Bahn, E-S Shin, J-E Lee, H-B Oh, Y-K Kim, T Park, S-H Cho, et al. Association of genetic variations in neurokinin-2 receptor with enhanced cough sensitivity to capsaicin in chronic cough Thorax, December 1, 2006; 61(12): 1070 - 1075. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Smith, E. Owen, J. Earis, and A. Woodcock Cough in COPD: Correlation of Objective Monitoring With Cough Challenge and Subjective Assessments. Chest, August 1, 2006; 130(2): 379 - 385. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Oshima, Y. Kasuya, Y. Okumura, T. Murakami, and S. Dohi Identification of independent risk factors for fentanyl-induced cough: [L'identification de facteurs de risque independants pour la toux induite par le fentanyl]. Can J Anesth, August 1, 2006; 53(8): 753 - 758. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Gatti, E. Andre, S. Amadesi, T. Q. Dinh, A. Fischer, N. W. Bunnett, S. Harrison, P. Geppetti, and M. Trevisani Protease-activated receptor-2 activation exaggerates TRPV1-mediated cough in guinea pigs J Appl Physiol, August 1, 2006; 101(2): 506 - 511. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A Torrego, R A Haque, L T Nguyen, M Hew, D H Carr, R Wilson, and K F Chung Capsaicin cough sensitivity in bronchiectasis Thorax, August 1, 2006; 61(8): 706 - 709. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Johansson, E. Millqvist, S. Nordin, and M. Bende Relationship Between Self-Reported Odor Intolerance and Sensitivity to Inhaled Capsaicin: Proposed Definition of Airway Sensory Hyperreactivity and Estimation of Its Prevalence Chest, June 1, 2006; 129(6): 1623 - 1628. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. Braman Chronic Cough Due to Chronic Bronchitis: ACCP Evidence-Based Clinical Practice Guidelines Chest, January 1, 2006; 129(1_suppl): 104S - 115S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Irwin Assessing Cough Severity and Efficacy of Therapy in Clinical Research: ACCP Evidence-Based Clinical Practice Guidelines Chest, January 1, 2006; 129(1_suppl): 232S - 237S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. J. Undem and M. Kollarik The Role of Vagal Afferent Nerves in Chronic Obstructive Pulmonary Disease Proceedings of the ATS, November 1, 2005; 2(4): 355 - 360. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. V. Dicpinigaitis and R. V. Alva Safety of Capsaicin Cough Challenge Testing Chest, July 1, 2005; 128(1): 196 - 202. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Prudon, S. S. Birring, D. D. Vara, A. P. Hall, J. P. Thompson, and I. D. Pavord Cough and Glottic-Stop Reflex Sensitivity in Health and Disease Chest, February 1, 2005; 127(2): 550 - 557. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Trevisani, A Milan, R Gatti, A Zanasi, S Harrison, G Fontana, A H Morice, and P Geppetti Antitussive activity of iodo-resiniferatoxin in guinea pigs Thorax, September 1, 2004; 59(9): 769 - 772. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Trevisani, D. Gazzieri, F. Benvenuti, B. Campi, Q. T. Dinh, D. A. Groneberg, M. Rigoni, X. Emonds-Alt, C. Creminon, A. Fischer, et al. Ethanol Causes Inflammation in the Airways by a Neurogenic and TRPV1-Dependent Mechanism J. Pharmacol. Exp. Ther., June 1, 2004; 309(3): 1167 - 1173. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C M Barber, A D Curran, D Fishwick, A Niimi, and M Mishima Impaired cough reflex in patients with recurrent pneumonia Thorax, July 1, 2003; 58(7): 645 - 646. [Full Text]
|
|
|
|
|
|
S S Birring, B Prudon, A J Carr, S J Singh, M D L Morgan, and I D Pavord Development of a symptom specific health status measure for patients with chronic cough: Leicester Cough Questionnaire (LCQ) Thorax, April 1, 2003; 58(4): 339 - 343. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H Minoguchi, K Minoguchi, A Tanaka, H Matsuo, N Kihara, and M Adachi Cough receptor sensitivity to capsaicin does not change after allergen bronchoprovocation in allergic asthma Thorax, January 1, 2003; 58(1): 19 - 22. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Kastelik, R. H. Thompson, I. Aziz, J. C. Ojoo, A. E. Redington, and A. H. Morice Sex-related Differences in Cough Reflex Sensitivity in Patients with Chronic Cough Am. J. Respir. Crit. Care Med., October 1, 2002; 166(7): 961 - 964. [Abstract] [Full Text]
|
|
|
|
|
|
P V DICPINIGAITIS and P M A CALVERLEY Capsaicin responsiveness in asthma and COPD Thorax, February 1, 2001; 56(2): 161b - 161. [Full Text]
|
|
|
|
|
|
M J Doherty, R Mister, M G Pearson, and P M A Calverley Capsaicin induced cough in cryptogenic fibrosing alveolitis Thorax, December 1, 2000; 55(12): 1028 - 1032. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
