| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
|
|
|
|
|||||||||||||
|
|
|||||||||||||||
a University of
Kuopio, Department of Public Health and General Practice, Kuopio,
Finland, b Kuopio University Hospital,
Department of Pulmonary Diseases, Kuopio, Finland, c University of Oulu,
Department of Public Health Science and General Practice and Oulu
University Hospital, Unit of General Practice, Finland, d Laakso
Hospital, Helsinki, Finland
Correspondence to: Dr M Pelkonen, Univ. of Kuopio, Dept. of Public Health and General Practice, PO Box 1627, FIN-70211 Kuopio, Finland email: Margit.Pelkonen{at}uku.fi
Received 15 November 1999; Returned to authors 31 January 2000; Revised version received 3 April 2000; Accepted for publication 25 April 2000
BACKGROUND
Although it
is well known that impaired pulmonary function is a strong predictor of
mortality and that smoking decreases pulmonary function, little is
known about the long term effect of smoking cessation on mortality at
different levels of pulmonary function. We have studied the impact of
smoking cessation on mortality over the entire range of baseline
pulmonary function.
METHODSThe study
subjects consisted of men aged 40-59 at entry who were the Finnish
participants in the Seven Countries Study during 1959-89.
RESULTSIn all the
participants (n = 1582) impaired forced expiratory volume in 0.75 seconds (FEV0.75) was significantly associated with
increased all cause mortality. When those who gave up smoking during
the follow up period were compared with continuous smokers (n = 860)
all cause mortality was found to be decreased among those who quit. The
relative adjusted hazard (HR) was 0.71 (95% confidence interval 0.50 to 1.00). The median survival time in those who stopped smoking
compared with those who continued to smoke from 1969 onwards was 7.65, 7.59, and 6.30 years longer in the lowest, middle and highest tertiles
of adjusted FEV0.75 distribution, respectively. In those
who gave up smoking, mortality from cardiovascular causes was
significantly lower (HR 0.60 (95% CI 0.37 to 0.98)).
CONCLUSIONSThese
findings suggest that smokers across the entire range of pulmonary
function may increase their expectation of lifespan by giving up smoking.
This article has been cited by other articles:
|
|
 |
|
  R. P. Young, R. Hopkins, and T. E. Eaton Forced expiratory volume in one second: not just a lung function test but a marker of premature death from all causes Eur. Respir. J., October 1, 2007; 30(4): 616 - 622. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. G. Pasipanodya, T. L. Miller, M. Vecino, G. Munguia, R. Garmon, S. Bae, G. Drewyer, and S. E. Weis Pulmonary Impairment After Tuberculosis Chest, June 1, 2007; 131(6): 1817 - 1824. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Pelkonen, I.-L. Notkola, A. Nissinen, H. Tukiainen, and H. Koskela Thirty-Year Cumulative Incidence of Chronic Bronchitis and COPD in Relation to 30-Year Pulmonary Function and 40-Year Mortality: A Follow-up in Middle-Aged Rural Men. Chest, October 1, 2006; 130(4): 1129 - 1137. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M Bednarek, D Gorecka, J Wielgomas, M Czajkowska-Malinowska, J Regula, G Mieszko-Filipczyk, M Jasionowicz, R Bijata-Bronisz, M Lempicka-Jastrzebska, M Czajkowski, et al. Smokers with airway obstruction are more likely to quit smoking Thorax, October 1, 2006; 61(10): 869 - 873. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hoogendoorn, M. P. M. H. Rutten-van Molken, R. T. Hoogenveen, M. L. L. van Genugten, A. S. Buist, E. F. M. Wouters, and T. L. Feenstra A dynamic population model of disease progression in COPD Eur. Respir. J., August 1, 2005; 26(2): 223 - 233. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Pelkonen, I.-L. Notkola, T. Lakka, H. O. Tukiainen, P. Kivinen, and A. Nissinen Delaying Decline in Pulmonary Function with Physical Activity: A 25-Year Follow-up Am. J. Respir. Crit. Care Med., August 15, 2003; 168(4): 494 - 499. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D M Mannino, A S Buist, T L Petty, P L Enright, and S C Redd Lung function and mortality in the United States: data from the First National Health and Nutrition Examination Survey follow up study Thorax, May 1, 2003; 58(5): 388 - 393. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N S Godtfredsen, J Vestbo, M Osler, and E Prescott Risk of hospital admission for COPD following smoking cessation and reduction: a Danish population study Thorax, November 1, 2002; 57(11): 967 - 972. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 The United Kingdom Small Aneurysm Trial Participan Long-Term Outcomes of Immediate Repair Compared with Surveillance of Small Abdominal Aortic Aneurysms N. Engl. J. Med., May 9, 2002; 346(19): 1445 - 1452. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Pelkonen, I-L Notkola, H Tukiainen, M Tervahauta, J Tuomilehto, and A Nissinen Smoking cessation, decline in pulmonary function and total mortality: a 30 year follow up study among the Finnish cohorts of the Seven Countries Study Thorax, September 1, 2001; 56(9): 703 - 707. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N B Pride Smoking cessation: effects on symptoms, spirometry and future trends in COPD Thorax, September 1, 2001; 56(90002): ii7 - 10. [Full Text] [PDF]
|
|
|
|
 |
|
 L. Dow and S. Ebrahim Commentary: Lung function and risk of fatal and non-fatal stroke--The Copenhagen City Heart Study Int. J. Epidemiol., February 1, 2001; 30(1): 152 - 153. [Full Text] [PDF]
|
|
|
|
|
|
N R ANTHONISEN Smoking, lung function, and mortality Thorax, September 1, 2000; 55(9): 729 - 730. [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
