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ra
, N Akçakaya, 
Seçkin, Y Camc
olu, N Sarmurat, F Aksoy
Sükran Ciftligi
Sok, Onur Ap. No. 35/15, Bakirköy, Istanbul, Turkey
Correspondence to: Dr H Çokura
hcokugras{at}turkpediatri.org.tr
Received 15 February 2000; Returned to authors 20 June 2000; Revised version received 8 August 2000; Accepted for publication 20 September 2000
BACKGROUND
Few
studies have evaluated the asthmatic airway in childhood. The aim of
this study was to assess the histopathological changes occurring in the
bronchi of children with moderate asthma using light and electron microscopy.
METHODSBronchial
biopsy specimens from 10 children with moderate asthma (seven boys) of
mean (SD) age 9.3 (3.8) years (range 5-14) were examined by light and
electron microscopy. Patients had not had a respiratory infection for
at least one month and they had not been treated with steroids or
sodium cromoglycate for four weeks before the study. Bronchoscopy was
performed under general anaesthesia using a Karl Storz rigid paediatric
bronchoscope. Biopsy materials were stained with uracyl acetate and
lead citrate and evaluated under a Zeiss-10 electron microscope and
light microscope.
RESULTSThe most
important finding was thickening and hyalinisation of the basement
membrane in nine patients. The ciliated
epithelial cells showed loss of cilia in some cases. Overactive
fibroblasts were consistently found. Six patients had degranulating
mast cells and lymphocyte infiltration in the submucosa. Eosinophils
were seen in only one biopsy sample.
CONCLUSIONChildren
with moderate asthma develop bronchial inflammation similar to the
reaction observed in adults. However, in our study the inflammation was
rich in lymphocytes rather than eosinophils.
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