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Department of
Respirology, Department of Pathology, Vancouver General Hospital & Health Sciences Centre, The University of British Columbia, 2775 Heather Street, Vancouver, BC, V5Z 3J5 Canada
Correspondence to: Dr J Road, Department of Respirology, Vancouver General Hospital, 2775 Heather Street, Vancouver, British Columbia V52 3J5, Canada
Received 16 December 1999; Returned to authors 17 February 2000; Revised version received 20 March 2000; Accepted for publication 30 March 2000
Myositis associated with graft-versus-host-disease (GVHD)
typically presents with proximal muscle weakness, myalgias, and a
raised creatinine phosphokinase (CPK) level. We report a case of a 51 year old man who developed respiratory muscle weakness five years after
an allogeneic bone marrow transplant for multiple myeloma. His symptoms
included tachypnoea, abdominal paradox, and orthopnoea. Pulmonary
function tests revealed diminished vital capacity and maximal
inspiratory and expiratory pressures. Serum CPK levels were raised and
a peripheral muscle biopsy specimen was consistent with GVHD. He
improved with immunosuppressive therapy.
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