| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
|
|
|
|
|||||||||||||
|
|
|||||||||||||||
a Division of
Respiratory Medicine, Nottingham City Hospital, Nottingham University,
Nottingham NG5 1PB, UK, b Rheumatology Unit,
Nottingham City Hospital, Nottingham University, c Respiratory Medicine, Glenfield Hospital,
Leicester, UK
Correspondence to: Dr R Hubbard Richard.Hubbard{at}Nottingham.ac.uk
Received 16 August 2000; Returned to authors 24 January 2001; Revised version received 14 February 2001; Accepted for publication 15 February 2001
BACKGROUND
A survey of
overnight oximetry was conducted to estimate the prevalence of
nocturnal hypoxaemia in patients with cryptogenic fibrosing alveolitis
and to establish whether nocturnal hypoxaemia is related to quality of life.
METHODSAll patients
with cryptogenic fibrosing alveolitis attending Nottingham City
Hospital were invited to enter the study. Spirometric measurements and
capillary blood gas tensions were obtained and overnight oxygen
saturation was recorded at home. Quality of life was assessed using the
Short Form-36, Chronic Respiratory Questionnaire, Hospital Anxiety
Depression Scale, and Epworth Sleepiness Score questionnaires.
RESULTSSixty seven
eligible patients were identified and 50 agreed to enter the study,
although two were subsequently excluded because they already used
oxygen overnight. In the remaining 48 the mean (SD) overnight oxygen
saturation (SaO2) was 92.5 (4.3)% and the median number of dips greater than 4% per hour was 2.3 (interquartile range 1.5-5.3). Daytime oxygen level predicted mean overnight SaO2 (1.94%/kPa, 95% CI 1.22 to 2.66, p<0.001) but percentage predicted forced vital capacity (FVC) did not
(0.018%/% predicted FVC, 95% CI -0.04 to 0.08, p=0.5). Nocturnal
hypoxaemia was associated with decreased energy levels and impaired
daytime social and physical functioning, and these effects were
independent of FVC.
CONCLUSIONSNocturnal
hypoxaemia is common in patients with cryptogenic fibrosing alveolitis
and may have an impact on health related quality of life.
This article has been cited by other articles:
|
|
 |
|
  A U Wells, N Hirani, and on behalf of the BTS Interstitial Lung Disease Gui Interstitial lung disease guideline Thorax, September 1, 2008; 63(Suppl_5): v1 - v58. [Full Text] [PDF]
|
|
|
|
|
|
J J Swigris, W G Kuschner, S S Jacobs, S R Wilson, and M K Gould Health-related quality of life in patients with idiopathic pulmonary fibrosis: a systematic review Thorax, July 1, 2005; 60(7): 588 - 594. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. J. Swigris, M. K. Gould, and S. R. Wilson Health-Related Quality of Life Among Patients With Idiopathic Pulmonary Fibrosis Chest, January 1, 2005; 127(1): 284 - 294. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
