| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
|
|
|
|
|||||||||||||
|
|
|||||||||||||||
REVIEW SERIES |
1 Respiratory Medicine Unit, Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research, Cambridge CB2 2XY, UK
2 Division of Pulmonary and Critical Care, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 02116, USA
Correspondence to:
Dr R Mahadeva, Respiratory Medicine Unit, Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research, Cambridge CB2 2XY, UK;
rm232{at}cam.ac.uk
ABSTRACT
The use of genetically manipulated mice together with traditional animal studies are steadily increasing our knowledge of the factors important in determining alveolar formation and destruction in emphysema. A review of the animal models used to study emphysema is presented.
Keywords: pulmonary emphysema; chronic obstructive pulmonary disease animal models
This article has been cited by other articles:
|
|
 |
|
  Z. Hantos, A. Adamicza, T. Z. Janosi, M. V. Szabari, J. Tolnai, and B. Suki Lung volumes and respiratory mechanics in elastase-induced emphysema in mice J Appl Physiol, December 1, 2008; 105(6): 1864 - 1872. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. H. Brown, C. G. Irvin, G. B. Allen III, S. D. Shapiro, W. J. Martin, M. R. J. Kolb, D. M. Hyde, G. F. Nieman, D. D. Cody, M. Ishii, et al. An Official ATS Conference Proceedings: Advances in Small-Animal Imaging Application to Lung Pathophysiology Proceedings of the ATS, July 15, 2008; 5(5): 591 - 600. [Full Text] [PDF]
|
|
|
|
 |
|
 S. E. McGowan, A. J. Holmes, R. P. Mecham, and T. M. Ritty Arg-Gly-Asp-Containing Domains of Fibrillins-1 and -2 Distinctly Regulate Lung Fibroblast Migration Am. J. Respir. Cell Mol. Biol., April 1, 2008; 38(4): 435 - 445. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. R. Froese, K. Ask, R. Labiris, T. Farncombe, D. Warburton, M. D. Inman, J. Gauldie, and M. Kolb Three-dimensional computed tomography imaging in an animal model of emphysema Eur. Respir. J., December 1, 2007; 30(6): 1082 - 1089. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. S. Stevenson, C. Docx, R. Webster, C. Battram, D. Hynx, J. Giddings, P. R. Cooper, P. Chakravarty, I. Rahman, J. A. Marwick, et al. Comprehensive gene expression profiling of rat lung reveals distinct acute and chronic responses to cigarette smoke inhalation Am J Physiol Lung Cell Mol Physiol, November 1, 2007; 293(5): L1183 - L1193. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Curtis, C. M. Freeman, and J. C. Hogg The Immunopathogenesis of Chronic Obstructive Pulmonary Disease: Insights from Recent Research Proceedings of the ATS, October 1, 2007; 4(7): 512 - 521. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Khan, S. Kianpour, M. R. Stampfli, and L. J. Janssen Kinetics of in vitro bronchoconstriction in an elastolytic mouse model of emphysema Eur. Respir. J., October 1, 2007; 30(4): 691 - 700. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Borzone, L. Liberona, P. Olmos, C. Saez, M. Meneses, T. Reyes, R. Moreno, and C. Lisboa Rat and hamster species differences in susceptibility to elastase-induced pulmonary emphysema relate to differences in elastase inhibitory capacity Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2007; 293(3): R1342 - R1349. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Hoshino, S. Kato, N. Oka, H. Imaoka, T. Kinoshita, S. Takei, Y. Kitasato, T. Kawayama, T. Imaizumi, K. Yamada, et al. Pulmonary Inflammation and Emphysema: Role of the Cytokines IL-18 and IL-13 Am. J. Respir. Crit. Care Med., July 1, 2007; 176(1): 49 - 62. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Pinto-Plata, J. Toso, K. Lee, D. Park, J. Bilello, H. Mullerova, M. M De Souza, R. Vessey, and B. Celli Profiling serum biomarkers in patients with COPD: associations with clinical parameters Thorax, July 1, 2007; 62(7): 595 - 601. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. F. Andrade, A. P. Wong, T. K. Waddell, S. Keshavjee, and M. Liu Cell-based tissue engineering for lung regeneration Am J Physiol Lung Cell Mol Physiol, February 1, 2007; 292(2): L510 - L518. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Fehrenbach Animal models of pulmonary emphysema: a stereologist's perspective Eur. Respir. Rev., December 1, 2006; 15(101): 136 - 147. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Mandeville, J. Aubin, M. LeBlanc, M. Lalancette-Hebert, M.-F. Janelle, G. M. Tremblay, and L. Jeannotte Impact of the Loss of Hoxa5 Function on Lung Alveogenesis Am. J. Pathol., October 1, 2006; 169(4): 1312 - 1327. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Voelkel and L. Taraseviciene-Stewart Emphysema: An Autoimmune Vascular Disease? Proceedings of the ATS, April 1, 2005; 2(1): 23 - 25. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Taraseviciene-Stewart, R. Scerbavicius, K.-H. Choe, M. Moore, A. Sullivan, M. R. Nicolls, A. P. Fontenot, R. M. Tuder, and N. F. Voelkel An Animal Model of Autoimmune Emphysema Am. J. Respir. Crit. Care Med., April 1, 2005; 171(7): 734 - 742. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Spira, J. Beane, V. Pinto-Plata, A. Kadar, G. Liu, V. Shah, B. Celli, and J. S. Brody Gene Expression Profiling of Human Lung Tissue from Smokers with Severe Emphysema Am. J. Respir. Cell Mol. Biol., December 1, 2004; 31(6): 601 - 610. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. G. Belvisi Regulation of Inflammatory Cell Function by Corticosteroids Proceedings of the ATS, November 1, 2004; 1(3): 207 - 214. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Guerassimov, Y. Hoshino, Y. Takubo, A. Turcotte, M. Yamamoto, H. Ghezzo, A. Triantafillopoulos, K. Whittaker, J. R. Hoidal, and M. G. Cosio The Development of Emphysema in Cigarette Smoke-exposed Mice Is Strain Dependent Am. J. Respir. Crit. Care Med., November 1, 2004; 170(9): 974 - 980. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J A Wedzicha, S L Johnston, and D M Mitchell Annual report October 2002 to September 2003 Thorax, December 1, 2003; 58(12): 1015 - 1017. [Full Text] [PDF]
|
|
|
|
|
|
M. Luisetti You May Say That I Ain't Free--But It Don't Worry Me Am. J. Respir. Crit. Care Med., July 15, 2003; 168(2): 144 - 145. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
