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| The first 150 words of the full text of this article appear below. |
The elimination of unwanted cells is now
regarded as an essential component of many normal biological
programmes. These include embryonic remodelling, the removal of
autoreactive thymic T cells, and the disposal of senescent enterocytes
at the villus tip. Hence cell death, in particular apoptosis or
"programmed cell death", appears to be a prerequisite for
life.1 In the particular example of inflammation many of
the unique features of apoptosis, such as the retention of plasma
membrane integrity, the loss of the cytotoxic and secretory capacity of
the cell, and the ability of apoptotic cells to be recognised and
phagocytically removed, suggest that this remarkable process may play a
key role in limiting tissue injury and facilitating the successful
resolution of inflammation.2-5 Furthermore, the ingestion
of apoptotic cells by macrophages, unlike the uptake of other
biological and non-biological material, fails to induce a secretory or
pro-inflammatory response.6 7 Although a number of
different
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