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a Departamento
de Medicina, Universidád de Salamanca, Spain, b Department of
Immunology, Western Infirmary, Glasgow, UK, c Departamento
de Ciencias Médicas y Quirúrgicas, Universidad de Las Palmas de
Gran Canaria, Spain
Correspondence to: Professor Dr J L Pérez Arellano, Departamento de Ciencias Médicas y Quirúrgicas, Centro de Ciencias de la Salud, Plaza Dr Pasteur, Trasera Hospital Insular, 35080 Las Palmas de Gran Canaria, Spain.
| The first 150 words of the full text of this article appear below. |
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Introduction |
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Iron metabolism is of crucial importance in the biology and
pathophysiology of the lower respiratory tract. As with many other factors involved in inflammation, it is very important that an appropriate iron balance is maintained. Local deficiency could impair
growth and proliferation of cells responsible for the inflammatory response and tissue repair (lymphocytes and fibroblasts) and the synthesis of mediators (for example, arachidonic acid
derivatives).1 In contrast, excessive accumulation of
iron, especially in free form
that is, not bound to one of the
specific iron-binding proteinsfacilitates the generation of
potentially toxic hydroxyl radicals2 and increases the
ability of intracellular bacteria such as mycobacteria to
grow.3-5
Research into iron metabolism in the lower respiratory tract has
taken advantage of bronchoalveolar lavage, a technique by which it is
possible to obtain the cells and fluid lining the alveoli.
Determination of iron content in the alveolo-interstitial region shows
that 80% is present
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