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Thorax 1999;54:947-952 ( October )

Occasional review

Nasal nitric oxide in man

J O N Lundberg^a, E Weitzberg^b

^a Department of Physiology and Pharmacology, Karolinska Institute, 171 77 Stockholm, Sweden, ^b Department of Anesthesiology and Intensive Care, Karolinska Hospital 171 76 Stockholm, Sweden

Correspondence to: Dr J O N Lundberg.

The first 150 words of the full text of this article appear below.

	Introduction

The past decade has witnessed an explosion in the interest of biologists in the gas nitric oxide (NO). This highly reactive free radical, first considered only a noxious air pollutant, is produced in mammalian cells by specific enzymes and is believed to play a vital role in many biological events including regulation of blood flow, platelet function, immunity, and neurotransmission.^1 2 Direct measurement of NO in biological tissues is difficult to perform because this gas reacts rapidly with, for example, haemoglobin or other Fe²⁺-containing proteins. It is therefore often necessary to rely on indirect measurements in order to detect NO synthesis in vivo. Unlike the situation in most biological tissues where NO is rapidly destroyed, in the gas phase NO is fairly stable at low concentrations.³ NO produced in superficial structures of hollow organs will diffuse into the lumen and thus be detectable in gas collected from such organs.

The . . . [Full text of this article]

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