| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
|
|
|
|
|||||||||||||
|
|
|||||||||||||||
Immunological
Medicine Unit, Division of Medicine, ICSM, Hammersmith Hospital, London W12 0NN, UK
Correspondence to: Dr J D Gillmore.
| The first 150 words of the full text of this article appear below. |
 |
Introduction |
|---|
Amyloidosis is a generic term for a heterogeneous group of disorders associated with deposition of protein in an abnormal fibrillar form.1 The diverse spectrum of amyloid related diseases is now recognised to include Alzheimer's disease, type II diabetes, and the transmissible spongiform encephalopathies. Amyloidosis can be hereditary or acquired, localised or systemic, and potentially lethal or merely an incidental finding.
Amyloid deposits consist mainly of protein fibrils, the varying peptide
subunits of which constitute the basis for its classification (table
1).2 Despite much heterogeneity among their respective precursor proteins, all amyloid fibrils have a remarkably similar adopted ultrastructure and share many physicochemical properties attributable to their acquired rich 
-sheet content.3
Certain glycosaminoglycans (GAGs) are invariably associated with the
fibrils and, in addition, all amyloid deposits contain the normal
plasma protein serum amyloid P component (SAP). The specific binding interaction between SAP and all amyloid fibrils is the basis for
This article has been cited by other articles:
|
|
 |
|
  W. Y. Lee and R. A. Balk Diffuse Pulmonary Nodules in a 25-Year-Old Man With Diarrhea and Weight Loss Chest, May 1, 2008; 133(5): 1252 - 1255. [Full Text] [PDF]
|
|
|
|
 |
|
 L. Niepolski, A. E. Grzegorzewska, and J. Szymas Nodular pulmonary amyloidosis and Sjogren's syndrome in a patient treated with intermittent haemodialysis (IHD) Nephrol. Dial. Transplant., May 1, 2007; 22(5): 1485 - 1486. [Full Text] [PDF]
|
|
|
|
|
|
J. T. Daniels, J. D. Cury, and J. Diaz An Unusual Cause of Postobstructive Pneumonia Chest, March 1, 2007; 131(3): 930 - 933. [Full Text] [PDF]
|
|
|
|
 |
|
 G. P Georghiou, O. Boikov, B. A Vidne, and M. Saute Primary Pulmonary Amyloidosis Due to Low-Grade B Cell Lymphoma Asian Cardiovasc Thorac Ann, February 1, 2007; 15(1): 69 - 71. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H J Lachmann and P N Hawkins Amyloidosis and the lung Chronic Respiratory Disease, November 1, 2006; 3(4): 203 - 214. [Abstract] [PDF]
|
|
|
|
 |
|
 T Stone, J H Reynolds, and H J Williams Imaging of large and small airway diseases Imaging, September 1, 2006; 18(3): 139 - 150. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. C. Minogue, M. Morrisson, and M. Ansermino Laryngo-tracheo-bronchial stenosis in a patient with primary pulmonary amyloidosis: a case report and brief review: [Une stenose laryngo-tracheo-bronchique chez un patient atteint d'amylose pulmonaire primaire : une etude de cas et une breve revue] Can J Anesth, October 1, 2004; 51(8): 842 - 845. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. T. Monroe, R. Walia, R. A. Zlotecki, and M. A. Jantz Tracheobronchial Amyloidosis: A Case Report of Successful Treatment With External Beam Radiation Therapy Chest, February 1, 2004; 125(2): 784 - 789. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. White and E. J. Mark Case 10-2001- A 53-Year-Old Woman with Arthritis and Pulmonary Nodules N. Engl. J. Med., March 29, 2001; 344(13): 997 - 1004. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
