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Thorax 1999;54:452-457 ( May )

Occasional review

Pulse transit time: an appraisal of potential clinical applications

Robin P Smith,b Jérôme Argod,a Jean-Louis Pépin,a Patrick A Lévya

a Department of Respiratory Medicine, Sleep Laboratory and PRETA Laboratory, CHRU, Grenoble, France, b Respiratory Department, Bristol Royal Infirmary, Bristol, UK

Correspondence to: Professor PA Levy, EFCR, Pneumologie, Rez-de-chaussée-haut, CHRU, 38043 Grenoble, Cedex 9, France.

Received 29 July 1998; Returned to authors 23 October 1998; Revised version received 1 December 1998; Accepted for publication 2 December 1998

The first 150 words of the full text of this article appear below.

    Introduction

Current techniques for investigating patients with suspected sleep disordered breathing are inadequate. Not only are many of the tests expensive, but they are also cumbersome and many centres require these investigations to be performed in the sleep laboratory. At the heart of the problem is the difficulty in identifying and quantifying the spectrum of respiratory events responsible for the sleep fragmentation and disabling excessive daytime sleepiness that is characteristic of obstructive sleep apnoea and its related conditions. Obstructive apnoeic episodes are not usually difficult to detect, even when only a basic measure of respiratory effort such as thoracic and abdominal movement is used. On the other hand, correctly identifying obstructive hypopnoeas and episodes of upper airway resistance needs a sensitive measure of airflow and inspiratory effort. The measurement of swings in pleural pressure by oesophageal manometry is the current gold standard technique for detecting changes in inspiratory effort. However, the . . . [Full text of this article]




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