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| The first 150 words of the full text of this article appear below. |
Common environmental allergens stimulate IgE responses
and produce allergic disease, but the allergens that produce the most potent IgE responses in nature originate from helminthic
parasites.1 2 Since parasitic infection is endemic in the
majority of the world's population, the relationship between
helminthic infection and the IgE response is highly relevant to the
understanding of allergic diseases. There is a general consensus that
IgE antibody is an important component of the immune resistance to
helminthiasis,5-9 although some conflicting results have
been obtained.3 4 Local IgE reactions can create
unfavourable conditions in the gut for intestinal parasites, and IgE
can mediate the cytotoxic activity of eosinophils against parasitic
larvae. These observations have led to the concept that, from an
evolutionary perspective, the primary function of the allergic response
may be as part of an anti-parasitic protective mechanism, and allergic
disease may be the undesirable reaction towards otherwise inoffensive
environmental substances.10 In developed countries
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  J. Leonardi-Bee, D. Pritchard, J. Britton, and the Parasites in Asthma Collaboration Asthma and Current Intestinal Parasite Infection: Systematic Review and Meta-Analysis Am. J. Respir. Crit. Care Med., September 1, 2006; 174(5): 514 - 523. [Abstract] [Full Text] [PDF]
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 M. S. Wilson, M. D. Taylor, A. Balic, C. A.M. Finney, J. R. Lamb, and R. M. Maizels Suppression of allergic airway inflammation by helminth-induced regulatory T cells J. Exp. Med., November 7, 2005; 202(9): 1199 - 1212. [Abstract] [Full Text] [PDF]
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L. J. Palmer, J. C. Celedon, S. T. Weiss, B. Wang, Z. Fang, and X. Xu Ascaris lumbricoides Infection Is Associated with Increased Risk of Childhood Asthma and Atopy in Rural China Am. J. Respir. Crit. Care Med., June 1, 2002; 165(11): 1489 - 1493. [Abstract] [Full Text] [PDF]
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 T Melsom, L Brinch, J O Hessen, M A Schei, N Kolstrup, B K Jacobsen, C Svanes, and M R Pandey Asthma and indoor environment in Nepal Thorax, June 1, 2001; 56(6): 477 - 481. [Abstract] [Full Text]
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