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Thorax 1999;54:730-736 ( August )

Occasional review

Long acting ₂ agonists and theophylline in stable chronic obstructive pulmonary disease

Mario Cazzola, Claudio Ferdinando Donner, Maria Gabriella Matera

The first 150 words of the full text of this article appear below.

	Introduction

The natural history of chronic obstructive pulmonary disease (COPD) is characterised by an accelerated annual decline in forced expiratory volume in one second (FEV₁). One of the most crucial factors in COPD is therefore the means by which this annual decline can be delayed. Bronchodilator therapy is usually prescribed to relieve the symptoms, reverse airway obstruction and, hopefully, to slow the rate of disease progression and decelerate the decline in pulmonary function. However, the Lung Health Study, in its five year observation of almost 6000 patients at risk of developing COPD,¹ reported that the rate of decline of lung function in smokers with mild to moderate COPD could be significantly slowed by smoking cessation but not by bronchodilator therapy.

Nonetheless, bronchodilators are an important form of treatment to reduce symptoms in COPD. As any improvement in airflow might be extremely important in these patients, the recent BTS guidelines for the . . . [Full text of this article]

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