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Department of
Respiratory Medicine, Queen Elizabeth Hospital, Birmingham B15
2TH, UK
Correspondence to: Professor R Stockley r.a.stockley@bham.ac.uk
| The first 150 words of the full text of this article appear below. |
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Introduction |
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Airway inflammation in chronic obstructive pulmonary disease (COPD) is currently the subject of rapidly increasing research interest, investigating both the nature of the inflammatory cells and the cytokines present. The data are being used to define and assess the severity, cause, prognosis, and response to treatment of this disease. The collection of spontaneous sputum or the induction of sputum has been used to study inflammation in the larger airways. It remains unclear, however, how these data relate to the pathological processes at the site of airflow obstruction (the small airways and alveolar region). Nevertheless, even the interpretation of the results from the large airways depends on the many factors that will influence the inflammation.
The initial process of sputum collection, sample processing, and the
performance of assays in the biological fluids being tested may all
influence the results. In addition, airways inflammation may be altered
by the patient's clinical state,
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