| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
|
|
|
|
|||||||||||||
|
|
|||||||||||||||
10
Interstitial Lung
Disease Center, Division of Pulmonary Sciences and Critical Care
Medicine, National Jewish Medical and Research Center and University of
Colorado Health Sciences Center, Denver, Colorado 80262, USA
Correspondence to: Dr M I Schwarz email: marvin.schwarz@uchsc.edu
| The first 150 words of the full text of this article appear below. |
 |
Definition and aetiologies |
|---|
The small vessel vasculitides of the lungs1-3 (table
1) are inflammatory destructive processes that affect the
arterioles, venules, and alveolar capillaries located within the
interstitial compartment. An intense infiltration of activated
neutrophils results in fibrinoid necrosis and dissolution of arteriolar
and venular walls, thus compromising the vascular lumen. Accompanying the arteriolitis and venulitis is a distinct interstitial (alveolar wall) component referred to as necrotising pulmonary
capillaritis.4-9 Necrotising pulmonary capillaritis can
occur in isolation, in the absence of histological evidence of
arteriolitis or venulitis. It is recognised by a marked interstitial
neutrophilic infiltration and many of these cells are undergoing
leucocytoclasis or fragmentation (fig 1). Because these neutrophils are
constantly undergoing cell death (apoptosis), pyknotic cells and
nuclear fragments (dust) accumulate within the lung parenchyma. The
interstitial space becomes broadened by oedema, fibrin, and the
neutrophilic infiltrate and eventually undergoes fibrinoid necrosis
(fig 2). During this process the
This article has been cited by other articles:
|
|
 |
|
  O. C. IOACHIMESCU and J. K. STOLLER Diffuse alveolar hemorrhage: Diagnosing it and finding the cause Cleveland Clinic Journal of Medicine, April 1, 2008; 75(4): 258 - 280. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Miyawaki, J. Shiraishi, Y. Tsutsumi, E. Shiraishi, K. Ohtsuki, M. Inoue, T. Tatsumi, A. Azuma, and H. Matsubara Beneficial Effect of Gabexate Mesilate on Microscopic Polyangiitis With Renal Dysfunction and Pulmonary Hemorrhage: A Case Report Angiology, August 1, 2006; 57(4): 522 - 525. [Abstract] [PDF]
|
|
|
|
 |
|
 D. R. Thickett, A. G. Richter, N. Nathani, G. D. Perkins, and L. Harper Pulmonary manifestations of anti-neutrophil cytoplasmic antibody (ANCA)-positive vasculitis Rheumatology, March 1, 2006; 45(3): 261 - 268. [Full Text] [PDF]
|
|
|
|
 |
|
 K. K. Brown Pulmonary vasculitis. Proceedings of the ATS, January 1, 2006; 3(1): 48 - 57. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Q. See, H. A. Jaffe, and D. E. Schraufnagel Dyspnea and Hemoptysis Develop in a Young Man With Prostatitis Chest, November 1, 2005; 128(5): 3625 - 3628. [Full Text] [PDF]
|
|
|
|
|
|
M. I. Schwarz and R. K. Albert "Imitators" of the ARDS: Implications for Diagnosis and Treatment Chest, April 1, 2004; 125(4): 1530 - 1535. [Full Text] [PDF]
|
|
|
|
 |
|
 J L Lordan, A Gascoigne, and P A Corris The pulmonary physician in critical care * Illustrative case 7: Assessment and management of massive haemoptysis Thorax, September 1, 2003; 58(9): 814 - 819. [Full Text] [PDF]
|
|
|
|
|
|
M Griffith and S Brett The pulmonary physician in critical care * Illustrative case 3: Pulmonary vasculitis Thorax, June 1, 2003; 58(6): 543 - 546. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. M. Hansell Small-Vessel Diseases of the Lung: CT-Pathologic Correlates Radiology, December 1, 2002; 225(3): 639 - 653. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
