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Service
de Pneumologie et de Réanimation Respiratoire, Hôpital Tenon, 4 rue
de la Chine, 75020 Paris, France
Correspondence to: Professor C Mayaud jacques.cadranel@tnn.ap.hop.paris.fr
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Introduction |
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The diagnostic and therapeutic approach to respiratory disease in the immunocompromised host remains a challenge for several reasons: (1) the current increase in both the number of immunocompromised hosts and their length of survival; (2) the high frequency of lung disease in these patients,1-3 and (3) the severity of these lung diseases.3-5 A good example is given in a recent review by Paterson et al of the epidemiology of invasive aspergillosis in transplant recipients.5 The incidence of this opportunistic infection, which mainly affects the lung, varies from 1% in kidney recipients to 9% in lung recipients (with 2% in liver recipients and 7% in bone marrow recipients). In this population it has a mortality rate of 55-92% and accounts for 10-15% of deaths of all transplant recipients.
In fact, the diagnostic challenge is continuously
evolving in the immunocompromised host and the following three
questions need to be considered: (1) What
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